About Zylö Therapeutics
Overview: Zylö Therapeutics has an innovative sustained-release drug-delivery system that was developed at Albert Einstein College of Medicine by Joel Friedman MD PhD and Adam Friedman MD FAAD. The patented delivery system uses hydrogel-derived nanoparticles, called Nanopods™, to deliver—in a sustained and controlled manner, for 24+ hours—notoriously hard-to-deliver therapeutic agents through topical administration.
The Universal Drug Delivery Platform: Drs. J. Friedman and A. Friedman set out originally to sustainably deliver Nitric Oxide, an unstable gas that has significant therapeutic potential. After investing more than 10 years and $10 million, the inventors achieved, with their second-generation Nanopod™ platform, sustained delivery of not only Nitric Oxide, but most any water- or fat-soluble molecule. In addition, they also achieved an important milestone of 24+ hours of sustained delivery, which is key for once-a-day application. Importantly, with this second-generation platform, the release rate of the payload is easily controlled, and the manufacturing of the Nanopods™ is easily scalable.
Problems solved!...There are two problems with almost all therapeutic agents we apply to the skin:
- Too much of the product stays on top of the skin, whereby the therapeutic agent either dissipates into thin air or gets rubbed off (by clothing, etc.)
- When the product actually gets absorbed into the skin, its “lasting power” is only 30-60 minutes
A Lidocaine-based cream (for hemorrhoidal pain/itch and other such inflammatory conditions) is a great example: After such a cream is applied, some stays on top of the skin and is ‘wasted,’ and the portion that gets absorbed has an effect that is less than one hour; as such, the user has to either live with the pain/itch for the rest of the day or re-apply many times per day (not easily performed and certainly not convenient).
By loading that same Lidocaine into our Nanopods™, however, one achieves a very different result: The Lidocaine-filled Nanopods™ immediately lodge themselves under the surface of the skin where it cannot be rubbed off, and the Nanopods™ slowly decompose, gradually releasing the Lidocaine over a 24+ hour period. Once-a-day application should relieve the pain/itch for an entire day.
Competitive advantages: The leading competitor is a $100M market-cap company that requires a two-part mixing chamber, has about 2-3 hours of sustainable delivery, has toxicity issues, and is limited to Nitric Oxide delivery and to dermatological applications. Zylö’s technology is far superior and has no market or payload limitations.
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