Multimillion-dollar grant to support heart health research at Clemson University see more
Clemson University bioengineers picked Valentine’s Day to announce $4.1 million in grants to support new heart health research.
Will Richardson and Naren Vyavahare are conducting research with the potential to affect millions of patients who suffer from many forms of cardiovascular disease and related illness, including heart failure, hypertension, chronic kidney disease and Type 2 diabetes, according to a university news release.
Richardson, an assistant professor of bioengineering, is creating computer models aimed at providing better treatment for cardiac fibrosis, a condition that contributes to heart failure. As many as 60% of patients die within five years of developing heart failure, which afflicts 6.5 million Americans, Richardson said in the news release.
No drugs have been approved to treat cardiac fibrosis specifically, and doctors are often left with trial-and-error experimentation when treating patients who have it, he said in the release.
Richardson said he hopes his research will lead to a day when measurements from a patient’s blood or tissue sample can be plugged into mathematical equations based on how molecules interact in the body. Overnight, patients would have personalized risk assessments and treatments plan, he said in the release.
Details about his research is available online.
Vyavahare, the Hunter Endowed Chair of Bioengineering, is working on what could be the first treatment to reverse vascular calcification, a condition that occurs when mineral deposits build up on blood vessel walls and stiffen them, according to the news release. It is most prevalent in aging patients and those with chronic kidney disease and Type 2 diabetes, Vyavahare said. Complications from vascular calcification can range from hypertension to death.
The nanoparticles that Vyavahare is developing are many times smaller than the width of a human hair and would deliver two medicines to calcified blood vessels. One medicine would remove the mineral deposits that cause blood vessels to become calcified, and another would return elasticity to the blood vessels.
More details about his work is online.
The Richardson and Vyavahare projects were both funded through the National Institutes of Health’s R01 program. Richardson is receiving $1.9 million, and Vyavahare is receiving $2.2 million, the news release said.
Anand Gramopadhye, dean of the College of Engineering, Computing and Applied Sciences, congratulated Richardson and Vyvahare on their grants.
Agneta Simionescu, an assistant professor of bioengineering, has also received $1.38 million through the R01 program. The Simionescu award was announced in November and is aimed at better understanding cardiovascular disease in patients with diabetes, the news release said.
Richardson and Simionescu were among the faculty members trained as part of SC BioCRAFT, a National Institutes of Health Center of Excellence. The center’s primary goal is to increase the number of South Carolina biomedical researchers who are supported by grants from the National Institutes of Health.
Vyavahare leads SC BioCRAFT, which stands for the South Carolina Bioengineering Center for Regeneration and Formation of Tissues.
SCBIO's Morgan Nichols is a STEM advocate, marketing guru and Miss America candidate. see more
CLEMSON, South Carolina – When Morgan Nichols takes the stage at the Miss South Carolina pageant this June, she will fulfill a dream – but maybe not the kind viewers would expect.
Nichols was recently named Miss Clemson and her excitement about the opportunity to showcase her passion for Science is evident in her platform “Stronger with STEM,” which inspires students to stick with STEM through exploration, education, and innovation.
Nichols is a Lexington, South Carolina, native and a senior in the College of Science‘s department of genetics and biochemistry. With a minor in business, she is blazing a career path that she is defining along the way.
SCBIO's Membership & Marketing intern is an emerging voice for life sciences in South Carolina. Read the full story here.
Purilogics President and Clemson Professor receives AICE’s highest grade of membership see more
Scott Husson of Clemson University is one of the newest Fellows in the American Institute of Chemical Engineers, the organization’s highest grade of membership.
Husson is Dean’s Professor in Clemson’s Department of Chemical and Biomolecular Engineering and president and founder of Purilogics, LLC.
Election as Fellow reaffirms the high esteem with which Husson’s colleagues and peers view his distinctive professional achievements and accomplishments, according to the institute.
“It is an honor to have been elected a Fellow of AIChE,” Husson said, using the institute’s acronym. “The institute has provided my students and me with abundant opportunities for professional growth and development over the years, which makes the recognition all the more special.
“It highlights the support, commitment, and contributions of my students, my colleagues and mentors, and my family. I am sincerely thankful to these individuals, the university, and my peers who nominated and selected me for this great honor.”
Husson’s research interests include membrane science and engineering, biologics recovery and purification, water purification and nuclear forensics.
He has served as principal investigator on 33 sponsored research projects and as co-principal investigator on 13 others, resulting in more $10 million in funding. Husson is the author of more than 90 journal publications and book chapters that have been cited more than 2,800 times.
He has been recognized as one of Clemson’s top teachers, winning the Clemson University Prince Award for Innovation in Teaching. He also won the Murray Stokely Award and Byars Prize for Excellence in Teaching Engineering Fundamentals, both from the College of Engineering, Computing and Applied Sciences.
Husson has advised 21 Ph.D. students, eight postdoctoral researchers and more than 70 undergraduate researchers.
His students have collectively won 24 national awards and 10 departmental honors. They have gone on to become university faculty members and to take positions in leading companies, his peers said.
David Bruce, chair of the Department of Chemical and Biomolecular Engineering, said election as Fellow was well deserved.
“Dr. Husson’s election confirms the exceptional level of scholarship and teaching he brings to Clemson,” Bruce said. “I offer my wholehearted congratulations to him.”
Husson has accumulated several awards in his career. They include the National Science Foundation’s Presidential Early Career Award for Scientists and Engineers; the FRI/John G. Kunesh Award; and several college-level awards, most recently the McQueen Quattlebaum Faculty Achievement and Collaboration awards.
Husson is active in professional societies, including the American Institute of Chemical Engineers. He has served on the Executive Committee of the North American Membrane Society as Treasurer since 2012 and as a member of its Board of Directors since 2010.
South Carolina’s $90-million research pipeline creates jobs and improves healthcare, researchers sayResearch pipeline adds jobs and improves healthcare in South Carolina see more
The $41.8 million that has flowed into Clemson University for three separate research centers could be the beginning of a larger enterprise that brings South Carolina new business, improved patient care and lower healthcare costs.
But success will hinge on how well some of the state’s largest institutions can work together, researchers said.
The funding comes from a National Institutes of Health program that is aimed at helping South Carolina, 22 other states and Puerto Rico establish Centers of Biomedical Research Excellence. Each has a specific research theme and can receive as much as $30 million distributed in three phases over 15 years. SC BioCRAFT, launched in 2009, has received two phases of funding totaling $20.3 million. Clemson officials announced Oct. 18 that SC-TRIMH received $11 million in its first phase of funding. EPIC started in 2015 with $10.5 million.
Those centers could be just the start of a continuous funding stream– a big one that transforms the South Carolina healthcare industry. Clemson officials are preparing to apply for a fourth center and have set a goal of continuously maintaining three centers. The plan would create a pipeline worth up to $90 million at any given time constantly flowing into South Carolina for biomedical research.
Clemson bioengineers lead two of the centers, SC BioCRAFT and SC-TRIMH. They said they rely on clinicians from Greenville Health System and the Medical University of South Carolina to guide their research, ensuring it remains relevant to what happens in real-world hospitals and clinics.
“Team effort is what is required,” said Naren Vyavahare, the director of SC BioCRAFT. “A lot of institutions are required for these big grants.”
One of the gems of the centers is that junior faculty members are mentored so that they can compete for their own federal funding. SC BioCRAFT is credited with mentoring 23 faculty members and generating $35 million in addition to the $20.3 million that funds the center itself. The center is also bearing fruit off campus. Research done at SC BioCRAFT has led to 16 patents, four spin-off companies and better care for patients suffering from ailments ranging from diabetes to traumatic brain injury.
The success of SC BioCRAFT could be a harbinger for the newest center, SC-TRIMH, which is led by Hai Yao, theErnest R. Norville Endowed Chair in Biomedical Engineering at Clemson.
A key part of SC-TRIMH’s mission is developing virtual human trials that would allow researchers to test new devices with computational models before trying them on humans. The idea is to close the gap between animal and human trials, allowing new devices to move from the lab to patients’ bedsides more quickly and less expensively. It’s an approach that has been used for drugs, but SC-TRIMH will be the first to try to apply it to medical devices, a step that could attract device manufacturers to the state, Yao said.
“The companies are going to come to us,” Yao said. “Why? Because we have the technology, and we have clinical partners here. So, we can test their products– not just test their products but use our technology to totally redesign their products.”
Initial research could apply to bad discs in the back, hip replacements and disorders of the temporomandibular joint, Yao said.
Martine LaBerge, chair of the Department of Bioengineering at Clemson, said SC-TRIMH could improve patient care for South Carolinians by staking a claim as a national leader in musculoskeletal health, the center’s primary focus.
“If we’re the leader, why would a patient need to fly to another state for treatment?” she asked. “We’ll become the leading health provider. Patients from other states may have to fly to South Carolina. This is our goal, and collaboration among institutions will be crucial to making it happen.”
Tanju Karanfil, vice president for research at Clemson, said officials are preparing to apply for a fourth center but will have to wait until 2020, because NIH rules limit each institution to three centers in the first two phases. He said that he is hopeful that SC BioCRAFT will receive Phase III funding.
“This is excellent for a university without a medical school,” Karanfil said. “Of course, with all credit, we are working with GHS, MUSC and USC. Their clinical expertise is indispensable.”
Vyavahare, the Hunter Endowed Chair at Clemson, took the lead in organizing the university’s first center, SC BioCRAFT, starting in 2006. The first proposal was rejected, and then a federal funding shortfall in 2008 put the program on hold for a year, he said. SC BioCRAFT received its first $10 million in 2009, and funding was renewed for the second phase five years later. Vyvahare said he is most proud of the center’s junior faculty.
SC BioCRAFT provided mentors who helped guide them through the research funding process, he said. The center also helped pay for new research equipment that is crucial to generating the data needed for a successful research proposal, Vyavahare said.
“It’s a good way to start your career quickly,” Vyavahare said. “A lot of people started getting good data, and everybody started getting funding.”
SC BioCRAFT is an acronym for the South Carolina Bioengineering Center for Regeneration and Formation of Tissues. SC-TRIMH stands for the South Carolina Center for Translational Research Improving Musculoskeletal Health. EPIC stands for Eukaryotic Pathogens Innovation Center.
Researchers said one of the key ingredients in the success of SC BioCRAFT and SC-TRIMH is Clemson’s deep integration with GHS and MUSC.
Both centers are based at the Clemson University Biomedical Engineering Innovation Campus, or CUBEInC, which is on the GHS Patewood Medical Campus in Greenville. Research is also conducted at MUSC, where Clemson has space in the medical university’s Bioengineering Building.
The value of collaboration was a consistent theme when researchers from the three institutions gathered to announce the creation of SC-TRIMH.
Scott Sasser, chief clinical officer for the GHS western region, said that Clemson was the health system’s primary research partner.
“That was by design, and it is unique,” he said. “We are so thankful for your investment in the medical school. The successful medical education of every student who walks through our doors is inextricably tied to your commitment to research that this project exemplifies.
“The novel methodology that will be used in this program will lead to new innovations and new devices that will not only change health outcomes but will help us all address the rising cost of healthcare in this country.”
Michael Kern, a professor in the Department of Regenerative Medicine and Cell Biology at MUSC, said what excites him most about SC-TRIMH is the chance to continue working with Yao.
“My research and Hai’s research before the COBRE grant have dovetailed nicely,” he said, using the acronym for the NIH funding program. “We’ve worked quite closely together for the previous 12 years. With the COBRE, we will be able to continue our work together to benefit young investigators and help them mature in their science.”
Kathleen Brady, associate provost for clinical and translational science at MUSC, said collaboration is part of a growing trend in research because it leads to success.
“When groups get together, studying a similar problem, you’re much more likely to come up with innovative solutions,” she said. “They are usually innovative solutions that neither group could have come up with on their own. SC-TRIMH is a perfect example of that– people with very different expertise coming together to do something unique and innovative.”
Spence Taylor, president of GHS, said in a written statement that working together can lead to significantly improved health care and health outcomes in South Carolina and the nation.
“These innovative partnerships between Clemson faculty and GHS clinicians allow us to solve clinical challenges by leveraging medical insights with the extraordinary research depth of Clemson,” he said. “What we do today can pave the way for transformational improvements to health care for generations to come.”
Vincent Pellegrini, chair of the Department of Orthopedics at MUSC, said much of the SC-TRIMH research will focus on musculoskeletal conditions that result from normal aging, including arthritis at the base of the thumb, hip replacement prostheses and tendon degeneration.
“The really exciting thing about the COBRE is that it juxtaposes the engineering, science and clinical medicine with the appropriate individuals in those disciplines on the same campus under the same roof to come up with real, clinically relevant devices and products that benefit patients,” he said.
Michael Kissenberth, a GHS orthopedic surgeon, said the collaboration will allow the institutions to complement each other
“We at GHS will be able to advise on the clinical needs that Clemson can then use to develop the technology that improves health outcomes,” he said. “In some cases, the technology may exist, and we can help show how it can be applied.”
Kyle Jeray, a GHS orthopedic surgeon, said SC-TRIMH will strengthen the collaborative spirit in South Carolina’s research community.
“Through SC-TRIMH, we will enhance the research infrastructure at Clemson and GHS by developing essential core facilities, fostering research collaborations and increasing scientific expertise of junior and senior faculty members,” he said.
Windsor Sherrill, associate vice president for Health Research at Clemson and chief science officer at GHS, said she wanted to recognize Tommy Gallien, the manager/coordinator for SC-TRIMH. She also wanted to acknowledge the Clemson University School of Health Research, or CUSHR.
“CUSHR is the interdisciplinary health research entity at Clemson that connects health researchers across colleges and departments with clinical researchers at health care systems such as GHS and MUSC,” she said. “The junior investigators for the SC-TRIMH initiative are from several different departments, ensuring that we have multidisciplinary focus to solve complex health care problems. The big challenges in health care do not fit neatly within one discipline or even in one university. SC-TRIMH is the kind of program we envision with CUSHR– one that leverages talents across Clemson health research faculty with the input of clinicians research at our partner institutions.”
Anand Gramopadhye, dean of the College of Engineering, Computing and Applied Sciences, congratulated Yao and his team on the SC-TRIMH grant.
“Through this grant, Dr. Yao and his team from Clemson, GHS and MUSC are strengthening the biomedical research capacity for South Carolina,” he said. “The award is a testament to the scholarship that Dr. Yao brings to Clemson and the power of collaboration to achieve the most innovative results.”
XLerateHealth partners with Clemson, Coastal Carolina, MUSC on regional biomedical technology accelerator hubState universities partner to create hub to accelerate commercialization of biomedical technologies see more
Industry and academic partners across the region on Thursday announced a federal grant that could potentially total $3.5 million over three years to create a hub to accelerate commercialization of biomedical technologies.
The grant, which includes nearly $500,000 in funding the first year, is being awarded by the National Institute of General Medical Sciences (NIGMS), a division of the National Institutes of Health (NIH).
XLerateHealth, LLC, a Louisville-based healthcare technology accelerator that focuses on startups and commercialization, is the primary awardee on the grant. XLerateHealth joined forces with a consortium of 24 academic institutions led by the University of Kentucky (UK), in partnership with the University of Louisville (UofL) and West Virginia University (WVU). Additional participants include Clemson University, Coastal Carolina University, and the Medical University of South Carolina. Read on for full details.
Clemson partnership extends reach to India and beyond see more
Clemson University researchers said a new partnership with one of India’s top engineering universities will lead to new medical devices, sensors and startup companies, while helping educate leaders and entrepreneurs for the global healthcare industry.
Clemson is joining with the Indian Institute of Technology Delhi to create the Center for Innovative Medical Devices and Sensors.
The long-term vision for the center includes exchanges of faculty members, students and post-doctoral researchers, and to eventually establish joint courses. Some of the first projects will focus on solutions for diabetes and other chronic health issues common to both countries.
The first exchanges could begin as soon as next summer.
Researchers plan to focus on technology that is close to going from the lab to the marketplace, a concept that scholars call translational research. The devices that researchers develop could lead to biomedical start-ups — and the lucrative jobs that come with them– in South Carolina and India, they said.
An advantage to cross-border research is that new technology will be designed to meet regulatory requirements in multiple countries, smoothing the transition to markets around the globe, said Delphine Dean, who is the Gregg-Graniteville Associate Professor of Bioengineering at Clemson.
The collaboration is the latest in a growing number of links between South Carolina and India, a connection that could help build both economies, she said.
“If a company wants to have a landing base to do FDA testing, South Carolina is a great area to do it in,” she said. “We have a lot of resources at the state level, and I think it will help drive economic development. When you go visit IIT Delhi, they know Clemson, and they know South Carolina.”
Dean is coordinating the center with Sandeep K. Jha, an assistant professor in the Centre for Biomedical Engineering at IIT Delhi.
Jha said the joint center with Clemson will be a win-win for both institutions and that they will develop several vital technologies by working together.
“The research and continual development in the field of medical sensors and devices is the need of the hour,” he said. “Most of the conventional technology related to healthcare and diagnostics have gradually been shifted towards automation, miniaturization and cost-effectiveness.
“In this regard, a research collaboration with Clemson University to develop cutting-edge medical technology would be beneficial for India, as it imports the majority of its medical devices and technologies. Medical devices and sensors could also help to meet several critical needs of South Carolina.”
For Clemson students, the opportunity to visit labs and do research in India will encourage global-scale thinking.
“If I were an undergrad, I’d think this was a great opportunity,” Dean said. “You go enjoy an experience in India and then you get your engineering degree. Then you’re a hot commodity for a job.”
IIT Delhi students will be visiting Clemson primarily for research, graduate studies and specialized bioengineering programs. Those programs include the Master of Engineering program and Green MD, an initiative focused on medical device recycling and reprocessing.
One of the attractions for IIT Delhi students is that they will have a chance to work with Clemson faculty who have extensive experience in translational research, said Brij Khorana, the chief scientific advisor for the College of Engineering, Computing and Applied Sciences at Clemson.
“By working with these Clemson faculty members, they will have the opportunity to gain entrepreneurial skills and participate in start-up businesses here, and then perhaps some of these students can go back to India and help with the healthcare industry there,” Khorana said. “Over time, this collaboration can just grow and grow.”
Some of the students’ work will be on the main campus, and some will be in Greenville at the Clemson University Biomedical Engineering Innovation Campus. The campus, also called CUBEInC, is at Greenville Health System’s Patewood campus.
Clemson’s close connection with clinicians at GHS and Medical University of South Carolina will be appealing to IIT Delhi students, Dean said. Clinicians play a crucial role in guiding research, ensuring that it reflects what happens in real-world hospitals and clinics.
Martine LaBerge, chair of the Department of Bioengineering at Clemson, said the new center will create a unique environment for healthcare education and research.
“The Center for Innovative Medical Devices and Sensors sets the stage for integrative learning and inventing experiences,” LaBerge said. “Students will learn the leadership, entrepreneurial and technical skills they will need to support and enhance a knowledge-based economy.”
The collaboration between Clemson and IIT Delhi brings together two institutions noted for their work in engineering and healthcare.
IIT Delhi was the third highest ranked Indian university in the latest QS World University Rankings. The institute also tied for No. 1 in engineering among Indian universities in the annual “Performance Ranking of Scientific Papers for World Universities” by National Taiwan University.
Clemson is renowned as the birthplace of the field of biomaterials and was among the first universities in the United States to start a bioengineering program, awarding its first Ph.D. in 1963. The university played a central role in creating the Society for Biomaterials.
Anand Gramopadhye, dean of Clemson’s College of Engineering, Computing and Applied Sciences, said the center will enable transformative research and deepen the talent pool for the healthcare industry.
“By coming together, Clemson and IIT Delhi will be able to accomplish much more than we could apart,” he said. “We are creating the conditions for a wider pipeline between academia and industry, as well as a healthier global society.”
SCRA Collaboration Center Awards feature numerous life science organizations from across the state. see more
South Carolina Research Authority’s SCRA-Academia Collaboration Team announces nearly $600,000 in feasibility grants for six projects. The awarded projects encourage collaboration between academic institutions and industry partners to advance commercially relevant research and establish the feasibility of the formation of Collaboration Centers. These Collaboration Centers will be founded for those areas demonstrating a critical mass of talent, infrastructure, financial resources, intellectual property and the prevalence of industry in South Carolina.
“These Feasibility Grants are the first step in establishing Collaboration Centers, which will garner national recognition for South Carolina, create jobs, engage industry and have an overall positive impact on the state.” said Christine Dixon Thiesing, Director of Academic Programs. “SCRA is fostering the growth of collaboration across academic institutions and between academia and industry through the support of six innovation projects.”
The Feasibility Grant Awards are the result of the efforts of the SACT, which was formed to deliver outcomes aligned with the Strategic Collaboration Agreement signed by SCRA and the presidents of the state’s research universities. The SACT is composed of representatives from the research universities, comprehensive teaching institutions, technical colleges, industry and SCRA. The SACT is currently evaluating the feasibility of establishing three Collaboration Centers – a Composites Industry Solutions Center, Medical Devices Collaboration Center, and Technology-Enabled Population Health Collaboration Center.
The list of grant awardees is below:
Composites Industry Solutions Center:
Collaboration among Clemson University, Greenville Technical College and industry partners Kistler Instrument Corp., Keyence Corporation of America and Renishaw.
Medical Devices Collaboration Center:
Collaboration between the Medical University of South Carolina and Clemson University.
Technology-Enabled Population Health Collaboration Center:
Collaboration among the Medical University of South Carolina, Trident Technical College and industry partners Zeriscope, Inc. and Amanda Senior Care.
Collaboration between Francis Marion University and a regional health organization as the industry partner.
Collaboration among University of South Carolina – Upstate and industry partners ChartSpan Medical Technologies and a state agency.
Collaboration among Clemson University, Florence-Darlington Technical College’s Southeastern Institute of Manufacturing and Technology and industry partner Greenville Health System.
Greenville-based Zylö Therapeutics is utilizing regional chemical/mechanical engineering in new ways see more
Once home to a thriving textile industry replete with chemical and mechanical engineers working to improve the soil and machinery converting raw cotton into commercial goods, upstate South Carolina may be on the precipice of its next industrial revolution: medtech.
Born from technology developed at the Albert Einstein College of Medicine, Greenville-based Zylö Therapeutics is utilizing the regional chemical/mechanical engineering expertise and support network to improve drug and nitric oxide delivery through a proprietary sustained delivery system called Nanopods.
Clemson University ranks fourth among America's 50 best value schools for biomedical engineering... see more
Clemson University came in fourth among the nation’s 50 best value schools for biomedical engineering, according to a new ranking from bestvalueschools.com.
The ranking included a variety of factors, including graduation rate, accreditation date, degree popularity, engineering popularity and net price.
Martine LaBerge, SCBIO Board Member and chair of the Department of Bioengineering at Clemson, said the ranking underscores that students are receiving a high-quality education that remains affordable.
“Best Value Schools has done an impeccable job of describing our program,” she said. “The ranking is a result of our faculty’s hard work and dedication to giving our students not only the best-in-class instruction and experience but also great value.”
The website advised students to “get ready to get hands-on at Clemson University.”
“Just about every day at Clemson includes some type of laboratory study, research project, or side-by-side work with faculty,” according to the site.
“Coursework doesn’t spare the details, either; the curriculum goes far beyond the basics to teach students about orthopedic implants, EKG simulations, medical treatment in developing countries, tissue engineering for human organs, and plenty of other topics that will immediately translate into the work environment.
“And students don’t have to wait until graduation to test out their skills. International partnerships enable budding engineers to conduct research in Singapore, work with mentors in Japan, or study bioethics in Spain.”
The department graduated 158 students last year, including 106 undergraduates, 37 master’s students and 15 doctoral students. It has 26 tenured or tenure-track faculty members conducting bioengineering research and clinically embedded education in partnership with the Greenville Health System and the Medical University of South Carolina.
Citing numbers from the U.S. Bureau of Labor Statistics, the website reported that demand for biomedical engineers will increase by nearly 25 percent by 2024, which it says is much faster than the average occupation. The average salary for specialists in the field is more than $85,000 a year, according to the site.
Clemson came in behind the Georgia Institute of Technology, Rice University, and the University of California-Irvine. The University of Utah rounded out the top five.
Anand Gramopadhye, dean of Clemson’s College of Engineering, Computing and Applied Sciences, congratulated the bioengineering department on the ranking.
“This is a well-deserved honor that underscores the high return on investment our students receive,” he said. “The college will continue to offer access to top faculty, world-class facilities and enriching experiences, while ensuring investment returns remain strong for our students and their families.”
To see the full list of rankings, go to: https://www.bestvalueschools.com/rankings/biomedical-engineering-degrees/.
South Carolina universities are making huge strides in designing better operating rooms for doctors see more
In an effort to design an operating room that increases patient safety and is easier for doctors to use, MUSC has been working with Clemson University on a four-year research project, which began in 2015, to study how doctors maneuver around operating rooms. Now the fruits of their talents and efforts are paying off. Read the full story.