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DPX Technologies

  • sam patrick posted an article
    DPX earns SBIR grant see more

    DPX Technologies, a manufacturer of laboratory consumables for sample preparation, receives over $250,000 from the National Science Foundation (NSF) for a Small Business Innovation Research (SBIR) Phase I project. The project involves rapid purification of RNA and the development of fast detection for COVID-19.

    RNA extraction is a key pre-analytical sample preparation step for viral RNA detection. Viral RNA detection is the current worldwide strategy used for early detection of the novel coronavirus SARS-Cov-2. The magnitude of the COVID-19 pandemic calls for unprecedented high throughput testing.

    DPX Technologies has been developing sample preparation products for high throughput, automated methods for over a decade. Their patented and proprietary pipette tip technology harnesses the power of automated liquid handlers to provide solutions for a variety of applications. DPX was able to leverage the help and expertise of Tyler Tatum at 3Phase SC. “Tyler helped with navigating through all of the paperwork and rules. He was great to work with and extremely knowledgeable,” said William Brewer, CEO of DPX Technologies and principal investigator on the SBIR Award.

    The South Carolina Department of Commerce Office of Innovation launched 3Phase in 2018 as a resource aimed at assisting research-based companies in South Carolina successfully acquire Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) awards. 3Phase provides training and workshops throughout the state on the federal SBIR and STTR programs, while managing the application process for a portfolio of companies, both at no cost to participants. The SBIR program funds early-stage research and development and is designed to provide equity-free funding. These investments stimulate technological innovation in the private sector, strengthening the role of small business in meeting federal research and development needs.*

    * Excerpt regarding information on 3Phase program from South Carolina Department of Commerce website and https://www.3phasesc.com/

    About DPX Technologies

    DPX is committed to providing innovative sample purification solutions. We collaborate with our customers to provide the high-quality products they need for complex chemical and biological analysis.

  • sam patrick posted an article
    DPX Technologies introduces new product line see more

    DPX Technologies, a manufacturer of laboratory consumables for sample preparation, announces the development of a new product line for size exclusion chromatography. The technology is patent-pending and utilizes a novel INTip swelling method that supports a hands-off approach for size exclusion chromatography workflows. The automated INTip swelling process allows the gel resin bed to be prepped and ready for sample application in less than 20 minutes.

    Size exclusion chromatography (SEC), also known as gel filtration, is a method by which molecules pass through SEC resin media and are separated by their size. The DPX methodology uses a group separation technique for desalting and buffer exchange where small molecules such as salts are separated from a group of larger molecules such as proteins. Desalting and buffer exchange are commonly used prior to affinity chromatography for antibody purification or polymerase chain reaction (PCR) cleanup. The new product line includes SEC pipette tips and automation accessories, offering a highly reproducible, automated solution for proteomics applications.

    Antibody testing and PCR cleanup are highly conversed topics due to the COVID- 19 pandemic, and DPX is committed to developing products that simplify and automate complex sample preparation for biological matrices. “This new product, along with INTip filtration products for Tip-on-Tip solid phase extraction, will help laboratories that need high throughput methods for processing thousands of samples daily, ” said Dr. Matthew Fitts, lead molecular biologist at DPX Technologies.

    DPX has been manufacturing pipette tips for sample preparation since 2007 and specializes in developing custom workflows for a diverse client base.

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    About DPX Technologies

    DPX is committed to providing innovative sample purification solutions. We collaborate with our customers to provide the high-quality products they need for complex chemical and biological analysis.

  • sam patrick posted an article
    DPX supporting higher education institutions and research facilities see more

    DPX Technologies, a manufacturer of laboratory consumable products for sample preparation, has awarded over $400,000 to researchers over the last several years. This amount is a combination of product donated and money awarded for researchers to use towards travel and presentations for industry specific scientific tradeshows or publications. DPX products have been featured in scientific publications including: Journal of Analytical Toxicology, Journal of Analytical and Bioanalytical Chemistry, and Journal of Chromatography.

    DPX manufactures patented sample preparation products and specializes in custom workflows for a diverse client base. The INTipTM products have attracted the attention of researchers for years. “We often get contacted by researchers that want to develop and publish new methods that use our technology. We welcome that collaboration,” says Dr. Kaylee Mastrianni.

    DPX wants to take a formalized approach in supporting higher education institutions and research facilities by awarding research grants to support the use of INTip sample preparation products as tools for education or discovery. DPX now has a form on their website to apply for research grants.

    Grants will be awarded based on the novelty and scientific impact of the research described in the application. Applications will be reviewed on a rolling basis throughout the year by the DPX scientific review board and recipients can be awarded up to $1000 per year. DPX Technologies will notify the winners by email and/or telephone. Multiple forms may be submitted by the same applicant, college/university or facility as long as the need demonstrated is for different applications.

  • sam patrick posted an article
    DPX publishes new application note see more

    DPX recently published a new application note “Automated Method for High-Throughput LC-MS/MS Quantitation of Testosterone from Serum: An Improved Validated Method” where a new ultra pure grade filtration tip was introduced. The method for the extraction of testosterone from serum used Low Porosity Filtration Tips- Ultra Pure (LPFT-UP) and incorporated a ZnSOsolution in addition to acetonitrile on a Hamilton Heater Shaker (HHS) for improved recovery and precision during protein precipitation. The LPFT-UP provide a high purity filtration media for methods with very low detection limits.

    Patient samples had a calculated recovery of testosterone at 99.5% with no detected matrix effects. This demonstrates that the use of ZnSO4 and acetonitrile is very efficient in extracting testosterone, and the use of ultra pure grade tips (LPFT-UP) resulted in negligible losses. The introduction of Low Porosity Filtration tips- Ultra Pure provides a new product for low detection level methods.

    “We are really excited to expand our product offering for steroid testing,” said Carmen Adamson, brand manager. DPX plans to expand on the research and development to include a full panel of steroids. “Testosterone imbalance can signal a problem in both men and women. This method provides an accurate and precise tool to aid in that determination,” said Evan DiVirgilio, application scientist. DPX continues to provide methods for efficient sample processing for clinical and forensic laboratories.

    DPX Technologies manufactures patented sample preparation products and specializes in custom workflows for a diverse client base including clinical, forensic, food safety, and pharmaceutical industries. Their products offer INTip™ sample preparation solutions that are compatible with semi-automated and fully automated liquid handling systems. This enables high sample throughput and high laboratory efficiency.

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    About DPX Technologies

    DPX is committed to providing innovative sample purification solutions. We collaborate with our customers to provide the high-quality products they need for complex chemical and biological analysis.

  • sam patrick posted an article
    DPX unveils new brand, website see more

    Columbia, SC – DPX Technologies, a manufacturer of laboratory consumable products, announces the launch of a new brand image. DPX has been manufacturing pipette tips for sample preparation since 2007. Their patented technologies are available across the U.S., and DPX plans to increase sales internationally.

    The rebrand includes a new company logo, website and other marketing collateral. DPX also updated the product lines with a trademark for the name INTip™. Product lines include INTip™ Solid Phase Extraction and INTip™ Filtration. This strategic brand update aligns product segments within different industries and highlights pipette tip technology for sample preparation.

    The future of DPX lies in the proteomics and genomics industries. Dr. Brewer sees a big future with INTip products for protein purification and DNA purification. “INTip compliments the existing core technology and delivers the new brand expansion for pipette tip products in market segments where automated sample preparation is highly sought after,” said Dr. Brewer, founder and CEO of DPX Technologies. “Pipette tips are easy to use and easy to automate, which will increase efficiency, robustness and reproducibility for protein purification and DNA purification.”

    DPX products are currently sold across the U.S., Canada and in Brazil. “We are starting to pick up leads in Europe, Australia and China. We are excited about expanding our product offerings internationally,” said Bill Kemnitzer, PhD., Director of Sales and Business Development.

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    About DPX Technologies

    DPX is committed to providing innovative sample purification solutions. We collaborate with our customers to provide the high-quality products they need for complex chemical and biological analysis.  Visit them at https://dpxtechnologies.com/

  • sam patrick posted an article
    DPX Technologies has invested more than $2.5 million and announced an expansion in Columbia, SC see more

    Columbia, SC – DPX Technologies, a manufacturer of laboratory consumable products, has invested more than $2.5 million and announced an expansion in Columbia, SC. The biotechnology company purchased and renovated a 12,000 sq. ft facility on 5 acres in the SCRA Carolina Research Park.

    DPX manufactures patented sample preparation products and specializes in custom workflows for a diverse client base including clinical, forensic, food safety, and pharmaceutical industries. Their products offer sample preparation solutions that are compatible with semi-automated and fully automated liquid handling systems. This enables high sample throughput and high laboratory efficiency.

    Read on for complete details on this story.

  • sam patrick posted an article
    A Columbia, SC-based biotech firm has introduced a new INTip solution with a proprietry design... see more

    Columbia, SCDPX Technologies announces a new INTip solution that utilizes a proprietary design for micro-elution dispersive solid phase extraction. DPX INTip solutions are designed to simplify sample preparation methods, and the μElution dSPE tip provides an automated solution for optimal sensitivity.

    “The μElution dSPE tips were developed as an addition to the dSPE product line, that give our customers the ability to reduce elution volumes and increase sensitivity for downstream analysis,” said William E. Brewer, Ph.D., Founder and CEO of DPX Technologies. “DPX micro-elution methods eliminate solvent evaporation and reduce the challenges for sample preparation of high throughput, high sensitivity assays.”

    Read the complete announcement here.