sam patrick posted an articleBARDA and FirstString Research announce partnership to repurpose aCT1 eye drops as a medical countermeasure against mustard gas keratopathyFirstString Research announces new partnership with BARDA see more
When responding to a chemical incident, mitigating long-term consequences of exposures is just as important as treating short-term injuries. BARDA and FirstString Research have partnered to repurpose Alpha-connexin Carboxyl-Terminal 1 (aCT1) eye drops as a potential medical countermeasure (MCM) against chronic eye injuries associated with sulfur mustard exposure.
Under BARDA’s Division of Research, Innovation, and Ventures (DRIVe) Repurposing Drugs in Response to Chemical Threats (ReDIRECT) program, BARDA will provide funding for proof-of-concept studies to evaluate the therapeutic potential of aCT1 eye drops in preclinical models of sulfur mustard corneal injury. aCT1 eye drops is the second compound to be investigated as a repurposing candidate under the ReDIRECT program, a partnership between DRIVe and the Chemical, Biological, Radiological, and Nuclear (CBRN) medical countermeasures Branch.
aCT1 is a synthetic peptide that has been shown to promote wound healing and temper pathological inflammation in the skin and eye. A topical formulation of aCT1, called Granexin® gel, is in late-stage trials (Phase 2/3) for indications of cutaneous radiation injury, cutaneous scarring from breast reduction surgery, and thermal burns.
aCT1 eye drops decrease inflammation (a common pathological response to chemical injuries such as sulfur mustard) and may promote regenerative ocular healing. Given that aCT1 displays anti-inflammatory effects for multiple indications within the field of regenerative medicine, the therapeutic potential of an ophthalmic formulation (aCT1 eye drops) will be investigated for long-term ocular injuries caused by vesicants (blister agents), specifically sulfur mustard.
In the aftermath of sulfur mustard exposure, acute injury to the cornea often resolves on its own within a few weeks. However, in some patients, a chronic condition may arise later once treatment stops. This delayed, recurring corneal injury, known as mustard gas keratopathy, is typically irreversible and can result in blindness. Repurposing aCT1 as an MCM against mustard gas keratopathy has the potential to improve the quality of life after chemical exposure by preventing the loss of eyesight.
These studies will aid in establishing rapidly deployable capabilities that can be used to reduce adverse health effects following ocular exposure to sulfur mustard.
About FirstString Research:
The following information is provided by the company and does not indicate endorsement by the federal government of the company or its products.
FirstString Research is an innovative biopharmaceutical company dedicated to discovering breakthrough therapies for inflammation and injury based medical conditions. The company is focused on developing and bringing to the market new therapeutic products that enable physicians to treat unmet medical needs. FirstString’s therapeutic approach aims at addressing disorders by mitigating excessive inflammation, calming the inflamed tissue, and rebooting the body’s normal injury response mechanism to enable rapid, regenerative. Learn more at https://firststringresearch.com/.
sam patrick posted an articleMount Pleasant's FirstString Research completes $15MM Series B financing see more
FirstString Research, a clinical-stage biopharmaceutical company, announced today that it has completed a $15 Million Series B financing round. Led by Park West Asset Management LLC and Sophos Capital Management L.P., the Series B financing round brings FirstString’s total investor funding to over $27 Million.
In connection with the Series B financing, Tony Bartsh of Park West and Neal McConnell of Sophos have joined FirstString’s Board of Directors. “FirstString’s team has developed impressive data for Granexin® across a wide range of wound healing indications. We believe the Series B capital will allow FirstString to accelerate the development pipeline in several promising areas. We look forward to the initiation of two important studies in the first half of 2018” said Tony Bartsh.
“We are thrilled to have Tony and Neal join our Board,” said Dr. Gautam Ghatnekar, President & CEO and Co-Founder of FirstString Research. “They bring with them a wealth of biopharmaceutical experience and expertise. We believe that the Park West and Sophos investments provide significant credibility and validation to our innovative technology and clinical strategy. With this new funding, FirstString will be able to continue our extensive pipeline development and to advance our existing late-stage clinical programs toward approval. ”