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therapeutic management

  • sam patrick posted an article
    Biotech startup receives top honors in category see more

    Elastrin Therapeutics of Simpsonville, SC has been named winner of the 2021 InnoVision Award for Technology Development, organizers have announced.

    Elastrin Therapeutics is a biotech startup with technologies to restore hardened and damaged arteries and tissue by targeting the elastic fiber that makes them work.

    Founded by Mr.Douglas Mulhall, Dr.Naren Vyavahare, Dr.Charles D. Rice, and Dr. Mirko Stange, the SCRA Client Company has demonstrated proof-of-concept for a patented therapeutic compound that may provide needed repair and restorative function to lungs that have been damaged by the COVID-19 virus. According to Vyavahare, “Elastin is present in lung alveoli that are being degraded by enzymes such as neutrophil elastases and MMPs released by inflammatory cells in COVID-19 infection of lungs. Our elastin targeting nanoparticle can also target drugs to the lungs and prevent lung injury.

    Click here to view the winner's video.

  • sam patrick posted an article
    Pall expects to hire even more associates in 2022 see more

    Compliments of Upstate Business Journal

    Pall Corporation announced Nov. 8 it will hire 300 people to staff its new 220,000-square-foot manufacturing facility at 816 Berry Shoals Road in Duncan.

    The facility manufactures products such as its Allegro platform, which may be used in the creation, purification and packaging processes for biotechnology and pharmaceutical products such as antibiotics, antibodies and vaccines, including COVID-19 vaccines.

    “We’re excited to join the Duncan community and welcome new associates to our growing team,” said Joseph Repp, president, Pall Life Sciences. “Pall has a proud, 75-year history of supporting development of life-saving vaccines and therapeutics. The important products we make here in South Carolina are used by customers around the world and critical to Pall’s global expansion plans as we increase production globally.”

    The company also expects to hire for additional positions in 2022.

    To apply for open positions, visit jobs.danaher.com/global/en and search for ‘South Carolina’ as the role location.

  • sam patrick posted an article
    FirstString Research announces new partnership with BARDA see more

    When responding to a chemical incident, mitigating long-term consequences of exposures is just as important as treating short-term injuries. BARDA and FirstString Research have partnered to repurpose Alpha-connexin Carboxyl-Terminal 1 (aCT1) eye drops as a potential medical countermeasure (MCM) against chronic eye injuries associated with sulfur mustard exposure.

    Under BARDA’s Division of Research, Innovation, and Ventures (DRIVe) Repurposing Drugs in Response to Chemical Threats (ReDIRECT) program, BARDA will provide funding for proof-of-concept studies to evaluate the therapeutic potential of aCT1 eye drops in preclinical models of sulfur mustard corneal injury. aCT1 eye drops is the second compound to be investigated as a repurposing candidate under the ReDIRECT program, a partnership between DRIVe and the Chemical, Biological, Radiological, and Nuclear (CBRN) medical countermeasures Branch.

    aCT1 is a synthetic peptide that has been shown to promote wound healing and temper pathological inflammation in the skin and eye. A topical formulation of aCT1, called Granexin® gel, is in late-stage trials (Phase 2/3) for indications of cutaneous radiation injury, cutaneous scarring from breast reduction surgery, and thermal burns.

    aCT1 eye drops decrease inflammation (a common pathological response to chemical injuries such as sulfur mustard) and may promote regenerative ocular healing. Given that aCT1 displays anti-inflammatory effects for multiple indications within the field of regenerative medicine, the therapeutic potential of an ophthalmic formulation (aCT1 eye drops) will be investigated for long-term ocular injuries caused by vesicants (blister agents), specifically sulfur mustard.

    In the aftermath of sulfur mustard exposure, acute injury to the cornea often resolves on its own within a few weeks. However, in some patients, a chronic condition may arise later once treatment stops. This delayed, recurring corneal injury, known as mustard gas keratopathy, is typically irreversible and can result in blindness. Repurposing aCT1 as an MCM against mustard gas keratopathy has the potential to improve the quality of life after chemical exposure by preventing the loss of eyesight.

    These studies will aid in establishing rapidly deployable capabilities that can be used to reduce adverse health effects following ocular exposure to sulfur mustard.

    This award is just one component of BARDA’s CBRN medical countermeasures and DRIVe’s medical countermeasures portfolios. Visit DRIVe’s ReDIRECT program to learn more.


    About FirstString Research:

    The following information is provided by the company and does not indicate endorsement by the federal government of the company or its products.

    FirstString Research is an innovative biopharmaceutical company dedicated to discovering breakthrough therapies for inflammation and injury based medical conditions. The company is focused on developing and bringing to the market new therapeutic products that enable physicians to treat unmet medical needs. FirstString’s therapeutic approach aims at addressing disorders by mitigating excessive inflammation, calming the inflamed tissue, and rebooting the body’s normal injury response mechanism to enable rapid, regenerative. Learn more at https://firststringresearch.com/.

  • sam patrick posted an article
    $30.2 million investment will create 425 new jobs see more

    Pall Corporation (Pall), a global leader in filtration, separation and purification, today announced plans to establish operations in Spartanburg County. The company is creating 425 new jobs and investing $30.2 million into a new facility that will support the rapid development and production of vaccines and therapeutics, including a COVID-19 vaccine.

    Pall serves the needs of customers across the broad spectrum of life sciences and industry and works with clients around the world to advance health, safety and environmentally responsible technologies.

    Located at 816 Berry Shoals Road in Duncan, Pall's new facility will focus primarily on single-use technology such as the Allegro™single-use platform.

    The facility is expected to be operational in May 2021. Individuals interested in joining the Pall team should visit the company's careers webpage.

    The Coordinating Council for Economic Development has approved job development credits related to the project.

    QUOTES

    "Spartanburg County provides Pall with the diverse workforce we need to manufacture life-saving therapeutics and vaccines. We look forward to building our presence in this county." -Pall Life Sciences President Joseph Repp

    "Pall Corporation's decision to invest into South Carolina comes at a time when our life sciences sector has evolved into one of our fastest-growing industries. The continued development of life sciences will create high-paying jobs that will ensure wellness and prosperity in South Carolina for years to come." -Gov. Henry McMaster

    "We could not be happier with Pall Corporation's decision to invest in Spartanburg County. We welcome this globally recognized company to South Carolina, and we look forward to partnering with them going forward." -Secretary of Commerce Bobby Hitt

    "The decision by Pall Corporation to come to Spartanburg is a win for our county, and a win for our budding life sciences sector. The variety of investments coming into our county, and the diversity of the industries that now call Spartanburg home, is a sign that our future is bright in the years to come." -Spartanburg County Councilman and Chairman of the Economic Development Committee David Britt

  • sam patrick posted an article
    Zylo, Hoth expand relationship see more

    Hoth Therapeutics, Inc. (NASDAQ: HOTH), a biopharmaceutical company, today announced it has completed a strategic investment in [SC Launch, Inc., Portfolio Company] Zylö Therapeutics, Inc. (“Zylö”).

    Mr. Robb Knie, Chief Executive Officer of Hoth, commented, “We are pleased to expand our partnership with Zylö and look forward to working together as our therapeutic for Lupus patients continues through the next phase of development. This small equity investment in Zylö is a further commitment to our belief in Zylö’s science and team.”

    Stated Scott Pancoast, CEO of Zylö Therapeutics, “Partnering with Hoth in 2019 was an important step in propelling our lupus program forward. This equity investment in Zylö stock represents an expansion of the partnership and is a win-win for the two companies.”

    According to estimates by the Lupus Foundation of America (LFA), 1.5 Million Americans currently suffer from lupus, with 16,000 new cases reported annually. Tragically, lupus strikes mostly women of child-bearing age. Worldwide, the LFA estimates that at least five million people may have some form of the disease. Of the people diagnosed, approximately two-thirds will develop CLE. The annual average cost to provide medical treatment for a person with lupus: $6,000 to $10,000, with some treatment costing several thousand dollars a month.

    ###

    About Zylö Therapeutics, Inc.
    Zylö, dedicated to bringing innovative technologies to multiple facets of medicine, has an innovative sustained-release drug-delivery system that was developed by Joel Friedman MD PhD, Adam Friedman MD FAAD, and Andrew Draganski PhD. The delivery system uses patented xerogel-derived nanoparticles, called Z-pods™, to deliver—in a sustained and controlled manner—notoriously hard-to-deliver therapeutic agents through topical administration. For more information, please visit; http://www.zylotherapeutics.com/

    About Hoth Therapeutics, Inc.
    Hoth Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on developing new generation therapies for dermatological disorders. HOTH’s pipeline has the potential to improve the quality of life for patients suffering from indications including atopic dermatitis, chronic wounds, psoriasis, asthma and acne. Hoth has recently entered into a Joint Development Agreement to further the development of vaccine prospects to prevent, intercept or treat the Coronavirus (COVID-19) based upon VaxCelerate, a self-assembling vaccine (SAV) platform exclusively licensed by Voltron from the Vaccine and Immunotherapy Center (VIC) at Massachusetts General Hospital (MGH). To learn more, please visit www.hoththerapeutics.com.

    Forward Looking Statements
    This press release includes “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements in this press release include, but are not limited to, statements that relate to the advancement and development of AEA-loaded Z-pods™, the commencement of clinical trials, the availability of data from clinical trials and other information that is not historical information. When used herein, words such as “anticipate”, “being”, “will”, “plan”, “may”, “continue”, and similar expressions are intended to identify forward-looking statements. In addition, any statements or information that refer to expectations, beliefs, plans, projections, objectives, performance or other characterizations of future events or circumstances, including any underlying assumptions, are forward-looking. All forward-looking statements are based upon Hoth’s current expectations and various assumptions. Hoth believes there is a reasonable basis for its expectations and beliefs, but they are inherently uncertain. Hoth may not realize its expectations, and its beliefs may not prove correct. Actual results could differ materially from those described or implied by such forward-looking statements as a result of various important factors, including, without limitation, market conditions and the factors described under the caption “Risk Factors” in Hoth’s Form 10K for the period ending December 31, 2018, and Hoth’s other filings made with the Securities and Exchange Commission. Consequently, forward-looking statements should be regarded solely as Hoth’s current plans, estimates and beliefs. Investors should not place undue reliance on forward-looking statements. Hoth cannot guarantee future results, events, levels of activity, performance or achievements. Hoth does not undertake and specifically declines any obligation to update, republish, or revise any forward-looking statements to reflect new information, future events or circumstances or to reflect the occurrences of unanticipated events, except as may be required by law.

  • sam patrick posted an article
    Vikor Scientific names new CSO see more

    CHARLESTON, S.C. (PRWEB) AUGUST 07, 2019

    Bill W. Massey, Ph.D. will be joining Vikor Scientific™ as Chief Scientific Officer to provide scientific leadership for Vikor’s molecular diagnostic and therapeutic management services, lead Vikor’s clinical research efforts related to their strategic alliances in the pharmaceutical and healthcare industries and continue to develop their model of personalized healthcare.

    "I am very excited to be joining Vikor Scientific at this crucial point in their growth and evolution. They have an incredible vision to step beyond the traditional model for clinical laboratory services and to become the premier provider of therapeutic management services. This transition to becoming a partner with providers and healthcare organizations in the delivery of optimal, personalized care is paradigm changing and will set the standard for coordinated diagnostics and collaborative care," said Dr. Massey.

    Dr. Massey is a world-renowned neuropharmacologist, pharmacogeneticist, life sciences professional, inventor and entrepreneur. Dr. Massey received his Ph.D. in Pharmacology at the University of Arkansas for Medical Sciences and subsequently an investigator at the Pritzker School of Medicine’s Drug Abuse Research Center at The University of Chicago. Dr. Massey holds long-standing adjunct faculty appointments at the University of Arkansas for Medical Sciences (Associate Professor, Dept. of Pharmacology and Interdisciplinary Toxicology) and the University of Mississippi Medical Center (Clinical Assistant Professor, Dept. of Psychiatry).

    Dr. Massey has held leadership positions at Merck, Astra Merck, Quintiles, Scirex, Astra Zeneca, Scientific Commercialization, Litmus Molecular Design, SureGene, and GeneAlign. He has played a leadership role in placing 28 new drugs into human testing and 8 new drugs onto the market. Dr. Massey formerly held the Jack Martin, MD Research Professorship in Psychopharmacology at Vanderbilt University, where he conducted research into the genetics, biological basis and pharmacological treatment of schizophrenia and serious mental illness in collaboration with Dr. Herbert Y. Meltzer. Dr. Massey is currently a Visiting Scholar at the Feinberg School of Medicine’s Dept. of Psychiatry and Human Behavior at Northwestern University where he continues his research collaboration with Dr. Meltzer.

    Dr. Massey has been a leader in the field of pharmacogenetics and personalized medicine for over two decades. Dr. Massey invented an easy-to-use combinatorial pharmacogenetic algorithm that makes clinical use of PGx practical for any physician and is currently patenting a direct-to-consumer product for weight loss.