Zylö Therapeutic’s Scott Pancoast Shares Secrets of Innovation Economy

Zylö’s Scott Pancoast shares secrets gleaned from more than 20 years in the innovation economy

“Innovation” is much more than a buzzword for Zylö Therapeutics CEO and founder Scott Pancoast.

Armed with a degree in economics from the University of Virginia and an MBA from Harvard Business School, Pancoast eventually headed West three decades ago, where he left a traditional corporate setting to step into a role making venture investments for a family in San Diego, California.

“When I moved to San Diego to work for that family, I was doing something new to me and had to learn how to assess new technologies for possible investment,” Pancoast says.

For the next two decades, Pancoast learned the difference between “innovation” as an idea, and “innovation” as sound investment. “You have to know how to spot the difficult transition from new technology, whether patented or something that can be patented, to a point where a customer is willing to write a check to incorporate that technology into their product or process,” he says. “And that is an arduous process, and a lot of things must fall into place for it to work.”

Pancoast, who has guided Greenville-based Zylö’s patented “Z-pod” from nascent technology to late-stage startup and is in the middle taking the company’s first-ever consumer-based product to market, insists he is more innovative thinker than innovator.

“I have not innovated, per se, but I have an innovative way of looking at things,” he says. “I considered architecture at [University of Virginia], so there’s an element of the left-brain in me.” He says the true innovators are usually found at universities or in the research labs of medium and large companies, but the key is finding people who can manage and cultivate those innovations.

“What I do is develop innovation to the point that it has commercial value,” he says. “Some innovations don’t scale, or there is no real use for them. You might be able to make it in a test tube, but you can’t produce it by the barrel.”

Scott Pancoast Shares How to Convert Innovative Minds

One key to success is an ability to convert innovative minds, the “PhD types,” into his partners. “They know the science, and I listen to and learn from them,” Pancoast says. And in that process, a partnership forms as CEO becomes student, and scientist becomes teacher.

But innovation as a concept is often very misunderstood, he says. “In most cases, the technology must undergo scale-up. A company can count on somewhere between 10 and 50 issues arising during scale-up and they usually don’t know what those issues are nor whether they can be successfully overcome.”

It’s why Pancoast insists on building innovation teams made up of those with the right mix of intelligence, creativity, and troubleshooting. “I liken an early-stage startup to a daily roller- coaster ride,” he says, laughing. “And as you progress, those ups and downs, those twists and turns, can create a lot of anxiety, because early-stage startups aren’t profitable, mid-stage startups are rarely cash-flow positive, and there’s this element of having less money today than you did yesterday. It’s definitely not for everyone.”

But does being an innovation leader require magnetism?

“That’s a special characteristic,” he says. “I can’t say it’s a necessity for success, but the people who enjoy the best odds of success must first have credibility, authenticity, and humility. I encourage my team to disagree with me, and disagree among themselves, and robustly debate what is right for the company.”

Sometimes, it means raised voices, and in an innovator’s environment, debate is essential. “Because in some ways, innovation is a simply a quest for the truth, about making the best decision at a particular juncture.”

Up Next

Zylö is partnering with Greenville-based RedHype Creative Marketing Agency to bring “twentyfour,” the company’s new line of anti-aging consumer products, to market.

Recognized

In 2024, Pancoast was named Founder of the Year by the South Carolina Research Authority.

Written by: Rick Spruill

Photography by: Jack Robert Photography

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Paige Durham

SCbio is pleased to welcome Paige Durham to the team as communications coordinator to creatively and effectively communicate the value of the life science association’s programs and initiatives.

Durham will be responsible for developing and distributing high-quality content across multiple communications channels to build, advance and grow South Carolina’s life sciences industry, a key business sector for economic prosperity for the Palmetto State.

“SCbio is excited to welcome Paige to our team as our new communications coordinator. Paige brings fresh ideas and a strong background in communications that will be invaluable as we continue to strengthen our engagement with our audience,” said SCbio President and CEO James Chappell. “We are confident that her skills and experience will be crucial in advancing our communication strategies and supporting our mission.”

Before joining SCbio, Durham was the Membership and Communications Manager at the South Carolina Pharmacy Association (SCPhA), where she used her photography, design and writing skills to create content tailored to pharmacy professionals. Durham’s effective communication skills guaranteed the delivery of brand-specific material that captured the eye of her audience.

During her time at SCPhA, Durham created and edited the Palmetto Pharmacist Journal, using her creative vision to showcase members, educational institutions and industry news. Her communications efforts successfully gained new followers for the organization over the course of a year, increasing brand visibility and promoting the pharmacy profession.

Durham holds a Bachelor of Science in hospitality and tourism management and a Bachelor of Science in business administration from the College of Charleston.

Tamia Sumpter

Tamia is a driven senior undergraduate Bioengineering student currently enrolled at Clemson University. With a strong foundation in her field, she has honed her skills through hands-on experience in research and development at Eli Lilly & Company. During her time in the ADME department, Tamia contributed significantly by working on siRNAs and their applications in finding In Vitro-In Vivo Correlation (IVIVC). Looking ahead, Tamia has set her sights on a promising career in law. She aspires to specialize in Intellectual Property Law, with a particular focus on serving as in-house counsel for leading medical device or pharmaceutical companies. Her enthusiasm for this role is palpable as she prepares to embark on her legal journey! She is also a proud member of the Omicron Phi chapter of Delta Sigma Theta Sorority, Inc., PEER Mentor for Clemson PEER/WiSE, and currently serves as the President of Clemson Bioengineering Organization (CBO). With her unique blend of scientific knowledge and legal interests, Tamia is poised to make a meaningful impact in the healthcare and life sciences industries.